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Clinical Research

(CR-035) A Pilot Study of Lower Extremity Wounds Utilizing A Novel Nanoparticle Self-Assembling Peptide

Thursday, May 16, 2024

7:30 PM – 8:30 PM East Coast USA Time

Introduction: This pilot study using a Novel Nanoparticle Self-assembling peptide synthetic cellular tissue product was used in 10 patients with Post-Mohs surgical failures of the lower extremities. The use of the product was performed in a prospective-longitudinal pilot study with a single site center of the primary author. The purpose of this study was to demonstrate accelerated healing and increased wound closure rate of area reduction relative to the historical standard of care and to compare to industry standard CTP closure rates with other products.

Methods:

The 10 (n=10) patients were seen from April 2023 to December 2023. All patients had failed post-Mohs primary closure and subsequently an additional 4-6 weeks of secondary healing prior to enrollment in the study. Use of the nanoparticle synthetic peptide was then applied at weekly intervals for 8 weeks to determine percent area closure. Secondary dressings were standardized for the pilot study and all patients underwent vascular testing before enrollment.

Results:

All 10 patients closed their wound by application #6. There was zero cases of recurrence and there were no adverse side effects or infections post-application. Average percent area reduction of wound size was reduced 67%. All wounds by week 8 were 100% closed.

Discussion: