(WHS-P96) THE PROMOTION OF CRITICALLY COLONIZED WOUND HEALING BY CLEANSING WITH SOFORO-FINE BUBBLES
Friday, May 17, 2024
7:30 AM – 5:00 PM East Coast USA Time
Ultra-fine bubbles, measuring less than 1 µm in diameter, are stable and effective for cleansing various materials. Recently, a chemical method using sophorose lipids has been developed to generate ultra-fine bubbles, known as Soforo-fine bubbles (SFB). Previous reports have highlighted the efficient removal of in vitro biofilms by SFB. This study aims to demonstrate the practical utility of SFB in cleansing critically colonized wounds through two animal experiments. Two full-thickness wounds were created on the dorsal skin of a rat and cleansed daily with either SFB or control solutions. In Experiment 1, normal wounds were created to assess the safety of SFB. In Experiment 2, critically colonized wounds were prepared to demonstrate the effect of SFB on wound healing. In both experiments, the healing period and relative wound area were compared between the groups. This study was conducted with the approval of the Animal Experimentation Committee of the University of Tokyo. In Experiment 1, there was no difference in the healing period between groups (p = 0.178). On post-wounding days (PWDs) 9, 10, 12, and 14, the relative wound area was significantly smaller in the SFB group compared with the control group. In Experiment 2, the SFB group had a significantly shorter healing period (14.3 ± 0.50 days vs. 15.5 ± 0.58 days, p = 0.015) and a smaller wound area on PWDs 5, 6, 9, and 13 compared with the control group. These results indicate that cleansing with SFB has no negative effect on normal wound healing and, importantly, promotes healing in critically colonized wounds.