(LR-012) Efficacy of a Type 1 Bovine Collagen Powder in the Wound Healing Process
Thursday, May 16, 2024
7:30 PM – 8:30 PM East Coast USA Time
Introduction: Collagen is an important component of wound healing, as it promotes healing through the attraction of fibroblasts and granulation tissue formation. While there is evidence to suggest its’ effectiveness, the formulations and type of collagen best for wound healing is still debated.This study looked to evaluate the efficacy of a Bovine Type 1 collagen powder intended for use in wound healing
Methods: Six Gottingen minipigswere selected for the study and were randomized into two groups. Each minipig received eight10 mmwounds created through punch biopsy. The control group received a standard wound dressing,and the experimentalgroup received an 85mg dose ofcollagen powder placed into the wound before the standard wound dressing was applied. The wounds were redressed on Days 3,7, and 14, with the experimental group receiving a repeat application of the collagen powder prior to the dressing being applied. Wounds were evaluated at Days 3 and 7 for erythema and edema, and wound size reduction was evaluated at Days 3, 7, 14, 21, and 28.
Results: On day 3, erythema was present in 37.5% of wounds of the standard dressing compared to 8.3% of wounds with the collagen powder (χ2= 5.78, p= 0.016). By day 7, edema was seen in 33.3% of wounds in the control group compared to just 16% in the experimental group(χ2 = 1.79, p= 0.18). All wounds were closed by day 28, with the experimental group having a greater reduction in wound size compared to the control group (74.7% vs. 67.8%). All cell types indicative of wound healing (macrophages, lymphocytes, etc.) were comparable in both groups.
Discussion: The collagen powder reduced erythema and edema, as well as provided a greater reduction in wound size when compared to the standard wound dressing. This study suggests that collagen powder placed into the wound bed may promote wound healing and a reduction in the severity of the wound more effectively then the standard wound dressing, with no adverse effects seen.