(CS-085) Exploring the Therapeutic Potential of Three-Dimensional Decellularized Porcine Liver Grafts Through Mobile Multispectral Near-Infrared Spectroscopy: A Case Series

Amber Gephart, MSN FNP- C APRN; Stephen Bufano, RN BSN CSWD-C BASW; Nicole Curtis, RN BS CSWD-C; Ali Saberi, MD; Eric Roberts, DPM DABFAS FACFAS; Audrey Moyer-Harris, BSN RN MBA CWS

Introduction:

Chronic wounds affect millions of patients worldwide, placing a significant burden on healthcare resources1. Addressing the complexities associated with wounds extending to various underlying tissues, including deep, tunneling, and irregular wounds, poses unique challenges. This study aims to explore the therapeutic potential of three-dimensional (3D) grafts as a viable solution for such wounds. This case series explores the potential of skin substitutes using mobile multispectral near-infrared spectroscopy (NIRS) and thermal imaging, with a focus on the 3D grafts for deep and tunneling wounds.

Methods:

An FDA cleared class II medical device, handheld mobile multispectral near-infrared spectroscopy (NIRS) and thermal imaging device*, was utilized for measuring temperature and tissue oximetry (StO2) in a non-wound contact manner. The device used in this study also captured digital photographs. This case series assesses the effectiveness of an FDA-cleared skin substitute product** on the healing rate of deep, tunneling, and irregular wounds. Patients were longitudinally tracked to observe the healing trajectory, and relevant data, including demographics, clinical characteristics, and NIRS findings, were collected and analyzed.

Results:

NIRS imaging played a crucial role in visualizing and documenting the healing trajectory, illustrating variations in tissue oximetry and temperature after applying the skin substitute. Thermal imaging offered valuable insights, especially in highlighting temperature elevations associated with inflammatory reactions both at and around the wound site. Moreover, NIRS provided insights into the impact on surrounding wound tissues, enhancing our understanding of the local effects.

Discussion: The success of 3D grafts in deep and irregular wounds, monitored by NIRS, has significant clinical implications. The comprehensive visualization provided by NIRS in monitoring healing trajectories offers invaluable insights for healthcare professionals. Beyond indicating the current state of the wound, NIRS assists in determining whether the wound is progressing toward normal healing.