(CS-117) Novel Approach to Wound Healing Post Lower Extremity Amputation Using Three- Dimensional Collagen Wound Matrix

This abstract presents the use of Miro3D® Wound Matrix (Reprise Biomedical, Inc.,

Minneapolis, MN), a three-dimensional, porcine collagen matrix with 2 cm thickness, along with

Miro3D Fibers Wound Matrix, a blended version of Miro3D, as a beneficial solution for packing

and filling deep wound voids created post lower extremity amputation.

Methods:

A retrospective case series was conducted on three patients with large wounds post lower

extremity amputation treated with a three-dimensional, porcine-derived collagen wound

matrix. Data collected included patient demographics, comorbid conditions, previous

procedures and treatments, and wound characteristics. Healing rates, number of product

applications, additional surgical treatments used, and adverse events were also reviewed. The

protocol encompassed pre- and post-operative care, as well as comprehensive treatment

throughout the continuum of care to evaluate wound healing rates and closure.

Results:

Due to complications and comorbidities associated with diabetes mellitus and osteomyelitis,

patients underwent amputation of their metatarsal or toes, resulting in deep, cavernous

wounds following the surgery. All patients healed without complications after the application of

Miro3D and Miro3D Fibers. Postoperatively, the integration of Miro3D and Miro3D Fibers

resulted in wound healing and closure in an average of 48 days for each patient.

Discussion:

The three-dimensional, porcine collagen matrix, sold under the tradename Miro3D, is an

innovative technology designed to fill deep, tunneling, and irregular wounds. The unique

porous structure of the collagen matrix serves as a scaffold that enables conformity and rapid

integration into the wound bed. The application of Miro3D and Miro3D Fibers in a closed

wound, followed by standard wound care, has shown to be effective for treating these

challenging lower extremity wounds.