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Case Series/Study

(CS-100) Three-Dimensional Wound Matrix for Deep, Tunneling, and Challenging Wounds

Thursday, May 16, 2024

7:30 PM – 8:30 PM East Coast USA Time

Introduction: The United States spends an average of $26.8 billion per year on pressure ulcer treatment. Over 2.5 million people are affected, and nearly 65,000 people die yearly. [3] Pressure ulcers lead to costly complications and long admission stays, costing facilities ~ $75,000-150,000. [4] A three-dimensional (3D) porcine liver-derived matrix offers an intact collagen scaffold for wound beds in areas with tunneling and undermining. This innovative product aims to expedite healing in individuals suffering deep, challenging wounds, potentially saving significant healthcare costs. [1, 4] Here, we present a case study of a Stage 4 sacral and hip pressure ulcer treated with Miro3D*.

Methods:

We present a case of a 3-year progressive Stage 4 pressure ulcer of the sacrum and right hip in an 82-year-old female with paraplegia, Type II diabetes, and hypertension. The ulcer resulted from a complicated left limb injury that did not heal correctly, leading to a prolonged hospital stay. This resulted in a deep sacral ulcer, and later complicated by a right hip ulcer. The patient has undergone and failed conservative measures, offloading, skin substitutes, and hyperbaric oxygen treatments. Her progress has been complicated by hospitalizations, right hip osteomyelitis, and frequent antibiotic use with C. diff complications, resulting in multiple healthcare costs in aids and offloading equipment/supplies.

At the initiation of treatment, the sacral wound measured 2.4 x 1.7 x .3cm, with an undermining ridge from 10 to 4 o’clock. The right hip wound measured 4.3 x 4.1 x 1cm, with a posterior lateral tunneling tract of 1cm. In addition, the hip wound had an undermining ridge of 1.5cm from 12 to 3 o’clock. Miro3D was applied to both wounds.

Results:

Upon follow-up, there was 100% graft uptake weekly. Both wounds responded to the 3D wound matrix with noted decrease in tunneling, undermining depth, and overall wound size within just 3 weeks.

Discussion:

Reprise Biomedical’s 3D wound matrix is 2cm thick, designed to cover and replace volume deficits in challenging wounds. This wound matrix promotes neovascularization, increased granulation, and overall skin remodeling in a reduced time, contributing to reduced healthcare costs and a faster healing process. [1]