(CS-128) Use of Dehydrated Human Amnion/Chorion Membrane Allograft as a Biological Dressing in the Treatment of Post Traumatic Tendon exposed wounds

The prevalence of acute wounds and chronic conditions, such as diabetic foot ulcers (DFUs), pressure ulcers, and venous ulcers, is rapidly increasing. Among these, skin and soft tissue loss in the limbs, often leading to tendon-exposed wounds, is particularly common. These wounds, where the tendon membrane is compromised due to trauma or infection, are highly susceptible to bacterial contamination, necessitating prompt tendon repair and coverage to avert serious complications. Amniotic membrane therapy, recognized for its remarkable regenerative potential, has emerged as a promising approach in wound care. This case study delves into the use of amniotic membrane in treating tendon-exposed wounds, aiming to evaluate its effectiveness in facilitating tendon repair, reducing complications, and enhancing overall patient outcomes. By examining specific cases and their results, this study contributes to the growing understanding of the amniotic membrane's role in managing the complex challenges of tendon-exposed injuries.

Methods:

This case series involved two patients with tendon-exposed wounds treated with Dehydrated Human Amniotic Membrane (DHACM) allografts. In the spirit of executing good principles of wound bed preparation, each patient's wound was initially thoroughly debrided and irrigated prior to receiving weekly applications of DHACM. The graft was secured with an appropriate dressing to maintain moisture and prevent allograft displacement.

Results:

Complete wound closure in each patient was observed one week after the final DHACM application. The patient in Case 1 resolved following three applications of DHACM, while the patient in Case 2 resolved following eight applications. The healing process included erythema, improved granulation tissue formation and full re-epithelialization. Further, a reduction in pain, accompanied by improved range of motion was documented. No adverse events or severe side effects from DHACM were reported in either patient.

Discussion:

This case study highlights the efficacy of amniotic membrane therapy in healing tendon-exposed wounds. The amniotic membrane's regenerative properties significantly contribute to favorable healing outcomes. As a result, amniotic membrane therapy stands out as a promising treatment option in the management of tendon-exposed wounds, offering expedited healing, reduction of pain and functional recovery.