(CS-017) Use of Dehydrated Human Amnion/Chorion Membrane Allograft as a Biological Dressing in the Treatment of Radiation Induced Ulcers

Radiation therapy, while effective in cancer treatment, often leads to challenging side effects, notably radiation-induced ulcers. These ulcers can interrupt therapy, causing pain and delaying treatment. Effective management of these ulcers is essential for pain relief, timely wound healing, and the continuation of radiation therapy. Amniotic membrane therapy, recognized for its wound healing capabilities, presents a promising solution. This case study delves into the application of amniotic membrane in treating radiation-induced ulcers, focusing on its regenerative properties and effectiveness in healing radiation-damaged skin. Through detailed analysis of individual cases, the study aims to enrich the current understanding of managing radiation-induced ulcers and assess the role of amniotic membrane therapy in this specialized context.

Methods:

This case series examines two patients with radiation-induced ulcers treated with Dehydrated Human Amnion Chorion Membrane (DHACM) allografts. The treatment involved wound irrigation followed by a single application of DHACM, secured with a dressing to maintain moisture and prevent allograft displacement.

Results:

Complete closure of the ulcers was observed one week after DHACM application. Remarkably, each patient required only a single application of DHACM and was able to resume therapy. The healing process included erythema, granulation tissue formation, patchy re-epithelialization, and final coverage with thin, pink skin. No adverse events or severe side effects from DHACM were reported.

Discussion: